In 2016, Yokoyama made her professional debut as a voice actress, landing small roles in anime series and video games. Her early work included roles in series such as " D.Gray-man: RE-BORN" and "The Asterisk War." While these roles were relatively minor, they helped Yokoyama gain recognition and build her resume.

Driven by a desire for new forms of expression, Yokoyama transitioned from modeling to acting in . She took acting classes, participated in short films, and performed in local theater while continuing to model, before eventually dedicating herself to acting full-time. Beyond Kamen Rider Wizard , her acting credits include the television production La Leyenda Del Dragón Perdido and the 2016 romantic comedy film Aozora Yell .

Her early works primarily focused on fresh, schoolgirl, and girl-next-door themes, before she began experimenting with genres like the OL (office lady) series, housewife themes, and light drama. Her natural acting, sweet but not cloying voice, and infectious smile are often cited by fans as her main appeals. As of 2025-2026, her recent work has noticeably decreased, and she is no longer exclusively affiliated with any one studio, reportedly considering expanding into gravure (softcore) modeling, social media influencing, or live streaming.

In addition to her professional endeavors, Yokoyama is also dedicated to giving back to her community. She has participated in various charity events and campaigns, including:

One of the distinctive aspects of Yokoyama's art is her use of symbolism and metaphors. Her works often feature recurring motifs, such as the use of colors, animals, and natural elements, which add depth and complexity to her stories. This attention to detail has earned her a loyal fan base, who appreciate the layers of meaning hidden within her manga.

Whether she's taking on new and exciting roles or using her platform to make a positive impact, Mirei Yokoyama is an artist who will continue to inspire and captivate audiences for years to come. As the world of entertainment continues to evolve, one thing is certain: Mirei Yokoyama is here to stay, and her star is only on the rise.

Growing up in Tokyo, Yokoyama was exposed to the world of entertainment from a young age. She developed a passion for singing and acting, which led her to pursue a career in the entertainment industry. After completing her high school education, Yokoyama joined the talent agency, Amuse, Inc., which would become the launching pad for her successful career.